- Collection:
- Atlanta University and Clark Atlanta University Theses and Dissertations
- Title:
- The Localization of ZIC2 Protein in HEK293T Cells and E006AA Prostate Cancer Cell Line, 2019
- Creator:
- Lang, Jimmie
- Date of Original:
- 2019-05-20
- Subject:
- Degrees, Academic
Dissertations, Academic - Location:
- United States, Georgia, Fulton County, Atlanta, 33.749, -84.38798
- Medium:
- color photographs
- Type:
- Text
- Format:
- application/pdf
- Description:
- The Cancer Genomic Atlas (TGCA) states that nearly all prostate cancer is adenocarcinoma. Prostate cancer is measured on a Gleason score which indicates how likely it s that a tumor would spread. TGCA has produced data that shows that the protein ZIC2 has increased RNA expression in prostate cancer cells that have a Gleason score of 3 or higher. ZIC2 is primarily located in the central nervous system during development. Preliminary data was shown that ZIC2 can be introduced to HEK cells 293T cells when constructing a plasmid containing ZIC2 and a N-terminal GFP tag. It was seen that the protein ZIC2 was localized in the mitochondria, which was a contrast to previous studies where ZIC proteins were localized in the nucleus. It is hypothesized that ZIC2 changes localization when using a plasmid containing ZIC2.
- External Identifiers:
- Metadata URL:
- http://hdl.handle.net/20.500.12322/cau.td:2019_lang_jimmie
- Rights Holder:
- Clark Atlanta University
- Holding Institution:
- Atlanta University Center Robert W. Woodruff Library
- Rights:
-
