A Synthetic Development of Imidazo [1,5-a] Pyridine to Salts by Nucleophilic Substitution, 2019

Collection:
Atlanta University and Clark Atlanta University Theses and Dissertations
Title:
A Synthetic Development of Imidazo [1,5-a] Pyridine to Salts by Nucleophilic Substitution, 2019
Creator:
Alsalmi, Mulouk
Contributor to Resource:
Bu, Xiu R.
Date of Original:
2019-12
Subject:
Degrees, Academic
Dissertations, Academic
Location:
United States, Georgia, Fulton County, Atlanta, 33.749, -84.38798
Medium:
dissertations
theses
Type:
Text
Format:
application/pdf
Description:
Degree Type: thesis
Degree Name: Master of Science (MS)
Date of Degree: 2019
Granting Institution: Clark Atlanta University
Department/ School: Department of Chemistry
The development of novel imidazopyridines to quaternary ammonium is made by quaternization of the precursors 1,3-diphenylimidazo[1,5-a] pyridine (IMB) and 3-phenyl-1-(pyridin-2-yl) imidazole [1,5-a] pyridine (IMP) with methyl iodide and ethyl iodide. Usually N-alkylation reactions of pyridine or imidazole are performed in polar solvents (acetonitrile, methanol, ethanol, etc.). The reaction with iodomethane afforded the new imidazopyridine (IMPs) salts in high yield ranging from 70-72%. The structures of the synthesized compounds were confirmed with 1H NMR, 13C NMR and UV spectroscopy. The purity was confirmed using TLC. The resultant IMPs salts were soluble in water and some extent in polar solvents such as methanol, dimethyl sulfoxide (DMSO), dichloromethane, and acetone. They also exhibit higher melting point than the IMPs.
Metadata URL:
http://hdl.handle.net/20.500.12322/cau.td:2019_alsalmi_mulouk_f
Language:
eng
Holding Institution:
Clark Atlanta University
Rights:
Rights Statement information

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