Characterization of Pyrazinamide mono-resistant strains of Mycobacterium Tuberculosis complex isolates submitted to centers for disease control from United States public health laboratories for drug susceptibility testing, 2011

Collection:
Atlanta University and Clark Atlanta University Theses and Dissertations
Title:
Characterization of Pyrazinamide mono-resistant strains of Mycobacterium Tuberculosis complex isolates submitted to centers for disease control from United States public health laboratories for drug susceptibility testing, 2011
Creator:
Franklin, Jameelah Atiya
Contributor to Resource:
Logan, David A.
Campbell, Marjorie G.S.
Metchock, Beverly
Date of Original:
2011-05-01
Subject:
Degrees, Academic
Dissertations, Academic
Location:
United States, Georgia, Fulton County, Atlanta, 33.749, -84.38798
Medium:
dissertations
theses
Type:
Text
Format:
application/pdf
Description:
Degree Type: thesis
Degree Name: Master of Science (MS)
Date of Degree: 2011
Granting Institution: Clark Atlanta University
Department/ School: School of Arts and Sciences, Biology
Pyrazinamide (PZA) is an important first line drug for the treatment of tuberculosis. While isolates of Mycobacterium bovis are intrinsically resistant to PZA and susceptible to all other anti-tuberculosis drugs, Mycobacterium tuberculosis isolates resistant to PZA are usually resistant to other first line anti-tuberculosis drugs as well. However, rare strains of M tuberculosis resistant only to PZA have been described in a previous study. Recently, methodological problems with PZA testing have been described previously, and Centers for Disease Control and Prevention (CDC) has recognized an increase in submission of PZA mono-resistant M. tuberculosis isolates from US public health labs.
Metadata URL:
http://hdl.handle.net/20.500.12322/cau.td:2011_franklin_jameelah_a
Language:
eng
Holding Institution:
Clark Atlanta University
Rights:
Rights Statement information

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