- Collection:
- Atlanta University and Clark Atlanta University Theses and Dissertations
- Title:
- Proper intraperitoneal copper therapy and the survival of brindled variant of the mottled mouse as a model for Menkes kinky hair disease, 1979
- Creator:
- Everett, James
- Date of Original:
- 1979-08-01
- Subject:
- Degrees, Academic
Dissertations, Academic - Location:
- United States, Georgia, Fulton County, Atlanta, 33.749, -84.38798
- Medium:
- theses
- Type:
- Text
- Format:
- application/pdf
- Description:
- The Brindled variant of the mottled mutant mouse Mobr (Hunt et al., 1974) was used to study the effect of copper therapy on the survival of the affected male offspring. The male of this sex-linked inherited (copper malabsorption) disease survives for 14 days postnatally, and is a model for Menkes kinky hair disease (Menkes et al., 1962). Parenteral copper therapy in the human has led to the survival of one human baby with tremendous neurologic deficits (Cover Jutton, 1975). In these experiments, copper fed mothers did not survive after the copper levels approached or exceeded 100% of normal. Copper fed male offspring when injected according to a specific time table, have survived and are now being tested for virility. The copper containing enzymes tyrosinase, ceruloplasmin, superoxide dismutase and cytochrome oxidase which were deficient in the untreated male were normalized after treatment even in the males that did not survive. Although malabsorption of copper characterizes the disease, the therapeutic time table for reversibility of the disease process seems quite specific and evasive and must be addressed in the human disease. It is our hope that the findings presented here lend some support to the probability of being able to stop the phenotypic events which accompany this dread human disease.
- External Identifiers:
- Metadata URL:
- http://hdl.handle.net/20.500.12322/cau.td:1979_everett_james
- Rights Holder:
- Clark Atlanta University
- Holding Institution:
- Atlanta University Center Robert W. Woodruff Library
- Rights:
-
