Fabrication of Bioactive Surfaces by Functionalization of Electroactive and Surface-Active Block Copolymers

Collection:
Clark Atlanta University Faculty Publications
Title:
Fabrication of Bioactive Surfaces by Functionalization of Electroactive and Surface-Active Block Copolymers
Creator:
Olubi, Omotunde
London, Laurisa
Sannigrahi, Biswajit
Williams, Michael
Khan, Israt M.
Date of Original:
2014-01-01
Subject:
African Americans--Education (Higher)--Georgia
Clark Atlanta University
Location:
United States, Georgia, Fulton County, Atlanta, 33.749, -84.38798
Medium:
articles
Type:
Text
Format:
application/pdf
Description:
Abstract: Biofunctional block copolymers are becoming increasingly attractive materials as active components in biosensors and other nanoscale electronic devices. We have described two different classes of block copolymers with biofuctional properties. Biofunctionality for block copolymers is achieved through functionalization with appropriate biospecific ligands. We have synthesized block copolymers of electroactive poly(3-decylthiophene) and 2-hydroxyethyl methacrylate by atom transfer radical polymerization. The block copolymers were functionalized with the dinitrophenyl (DNP) groups, which are capable of binding to Immunoglobulin E (IgE) on cell surfaces. The block copolymers were shown to be redox active. Additionally, the triblock copolymer of ?, ?-bi-biotin (poly(ethylene oxide)-b-poly (styrene)-b-poly(ethylene oxide)) was also synthesized to study their capacity to bind fluorescently tagged avidin. The surface-active property of the poly(ethylene oxide) block improved the availability of the biotin functional groups on the polymer surfaces. Fluorescence microscopy observations confirm the specific binding of biotin with avidin.
Source: Bioengineering
DOI: 10.3390/bioengineering1030134
URL: http://www.mdpi.com/2306-5354/1/3/134
Metadata URL:
http://hdl.handle.net/20.500.12322/cau.ir:2014_olubi
Language:
eng
Original Collection:
Clark Atlanta University Faculty Publications
Holding Institution:
Clark Atlanta University
Rights:

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