- Atlanta University and Clark Atlanta University Theses and Dissertations
- The active role of cerebrospinal fluid, brain cells and tissue homogenates from the mid-brain of the chick embryo in negotiating physiological changes in osmotic pressure and viscosity via selective secretion of macromolecules, 1981
- Houston, Willie W.
- Contributor to Resource:
- Browne, John M.
- Date of Original:
- Degrees, Academic
- United States, Georgia, Fulton County, Atlanta, 33.749, -84.38798
- Degree Type: thesis
Degree Name: Doctor of Philosophy (PhD)
Date of Degree: 1981
Granting Institution: Atlanta University
In this investigation changes in inferred protein synthetic activity and its association with hyaluronic acid changes in chick brain development from 4 day-old embryos to 8 day-old embryos were studied in three parts: cerebrospinal fluid, brain cells and homogenized brain tissue. With the use of S-Methionine, it is apparent that during chick brain development the increase and changes associated with protein synthesis activity closely resembles the changes in all three components of the brain studied. The activity of hyaluronic acid was adequately assessed using C-Glucosamine and H-Glucosamine. The hyaluronic acid appeared strongly bound to the protein, and it appears that day 6 and 7 are critical periods in which protein synthesis and hyaluronic acid synthesis are either retarded or accelerated. Moreover, it is suggested that the changes noted in hyaluronic acid synthesis may be affected by changes in cell type, size, number, specific enzymes or waves of neuronal migration and differentiation during embryonic brain development.
- Metadata URL:
- Holding Institution:
- Clark Atlanta University