Intra-Tumoral Delivery of Functional ID4 Protein via PCL/ Maltodextrin Nano-Particle Inhibits Prostate Cancer Growth

Collection:
Clark Atlanta University Faculty Publications
Title:
Intra-Tumoral Delivery of Functional ID4 Protein via PCL/ Maltodextrin Nano-Particle Inhibits Prostate Cancer Growth
Creator:
Korang -Yeboah, Maxwell
Patel, Divya
Morton, Derrick
Sharma, Pankaj
Gorantla, Yamini
Joshi, Jugal
Nagappan, Perri
Pallaniappan, Ravi
Chaudhary, Jaideep
Date of Original:
2016-07-03
Subject:
African Americans--Education (Higher)--Georgia
Clark Atlanta University
Location:
United States, Georgia, Fulton County, Atlanta, 33.749, -84.38798
Medium:
articles
Type:
Text
Format:
application/pdf
Description:
Abstract: ID4, a helix loop helix transcriptional regulator has emerged as a tumor suppressor in prostate cancer. Epigenetic silencing of ID4 promotes prostate cancer whereas ectopic expression in prostate cancer cell lines blocks cancer phenotype. To directly investigate the anti-tumor property, full length human recombinant ID4 encapsulated in biodegradable Polycaprolactone/Maltodextrin (PCL-MD) nano-carrier was delivered to LNCaP cells in which the native ID4 was stably silenced (LNCaP(-)ID4). The cellular uptake of ID4 resulted in increased apoptosis, decreased proliferation and colony formation. Intratumoral delivery of PCL-MD ID4 into growing LNCaP(-)ID4 tumors in SCID mice significantly reduced the tumor volume compared to the tumors treated with chemotherapeutic Docetaxel. The study supports the feasibility of using nanocarrier encapsulated ID4 protein as a therapeutic. Mechanistically, ID4 may assimilate multiple regulatory pathways for example epigenetic re-programming, integration of multiple AR co-regulators or signaling pathways resulting in tumor suppressor activity of ID4.
Source: Oncotarget, Vol. 7, No. 42
DOI: 10.18632/oncotarget.10953
Metadata URL:
http://hdl.handle.net/20.500.12322/cau.ir:2016_yeboah_maxwell_k
Language:
eng
Original Collection:
Clark Atlanta University Faculty Publications
Holding Institution:
Clark Atlanta University
Rights:

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