Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome

Collection:
Clark Atlanta University Faculty Publications
Title:
Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome
Creator:
Seffens, William
Abebe, Fisseha
Evans, Chad
Wang, Xiao-Qian
Date of Original:
2016-06-08
Subject:
African Americans--Education (Higher)--Georgia
Clark Atlanta University
Location:
United States, Georgia, Fulton County, Atlanta, 33.749, -84.38798
Medium:
articles
Type:
Text
Format:
application/pdf
Description:
Abstract: RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression.
Source: International Journal of Molecular Sciences 17, no. 6 (2016): 1-11.
DOI: 10.3390/ijms17060830
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926364/pdf/ijms-17-00830.pdf
Metadata URL:
http://hdl.handle.net/20.500.12322/cau.ir:2016_seffens_william
Language:
eng
Original Collection:
Clark Atlanta University Faculty Publications
Holding Institution:
Clark Atlanta University
Rights:

Locations